Adam Lallana is again likely to be missing as he continues to struggle with a knee injury.
The Saints captain sat out Saturday's 1-0 home defeat to Sunderland and looks set to miss out on the trip to Craven Cottage.
But Nigel Adkins' side appeared to come through the defeat to the Black Cats without any new knocks.
Fulham boss Martin Jol is likely to make changes after a disappointing 4-0 defeat at Liverpool on Saturday.
Steve Sidwell is available again after serving a one-game suspension at Anfield and is expected to be restored to the starting line-up.
But Bryan Ruiz is a doubt and Mahamadou Diarra remains on the sidelines with Damien Duff for the Cottagers.
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