Southampton left-back Luke Shaw is a doubt for Saturday's clash with reigning Premier League champions Manchester City.
The 17-year-old picked up a ligament issue ahead of his England Under-21s debut against Sweden in midweek, while fellow full-back Nathaniel Clyne, another to drop out of the Young Lions' squad, may also be unavailable.
Gaston Ramirez and Guly do Prado are also possibly out, while Jose Fonte is sidelined.
Adam Lallana could make his first start since suffering a knee injury on December 8 and January acquisition Vegard Forren could make his debut.
City could be boosted by the return of captain Vincent Kompany after recovering from a calf injury.
Kompany returned to training on Wednesday and Roberto Mancini will make a decision on his fitness after training on Friday.
City are also boosted by the return of Yaya and Kolo Toure after returning from international duty at the Africa Cup of Nations with Ivory Coast.
Mancini must decide who to start with up front after leaving Carlos Tevez on the bench against Liverpool with Sergio Aguero and Edin Dzeko getting the nod in attack.
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