Changes are a distinct possibility after Villa's embarrassing defeat to Bradford on Tuesday.
Darren Bent is one enforced change to the squad after he suffered a knee injury at Valley Parade.
But there is better news regarding defender Ron Vlaar. The Dutchman trained on Thursday and is available for selection again.
Southampton will be without first-team regulars Jose Fonte and Adam Lallana when they travel to Villa Park.
The pair have knee injuries so will miss the trip to Villa Park, while Emmanuel Mayuka is unavailable after linking up with Zambia for the Africa Cup of Nations.
There is good news in regards to Gaston Ramirez and Nathaniel Clyne, who return from a dead leg and knee complaint respectively.
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